Medicine

Molecular classification to improve medical as well as radiotherapeutic decision-making in meningioma

.MacFeeters Hamilton Neuro-Oncology System, Princess Margaret Cancer Cells Centre, College Health System and also Educational Institution of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDivision of Neurosurgery, Department of Surgical Operation, College of Toronto, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehPrincess Margaret Cancer Center, Educational Institution Health And Wellness System, Toronto, Ontario, CanadaJustin Z. Wang, u00c2 Vikas Patil, u00c2 Alexander P. Landry, u00c2 Chloe Gui, u00c2 Andrew Ajisebutu, u00c2 Jeff Liu, u00c2 Rebeca Yakubov, u00c2 Ramneet Kaloti, u00c2 Farshad Nassiriu00c2 &amp u00c2 Gelareh ZadehDalla Lana Institution of Hygienics, University of Toronto, Toronto, Ontario, CanadaOlli SaarelaNRG Oncology Statistics and Data Management Center, Philly, , USAStephanie L. Pughu00c2 &amp u00c2 Minhee WonTemerty Institution of Medicine, Educational Institution of Toronto, Toronto, Ontario, CanadaZeel PatelNeurosurgery Specialists of Tulsa, Tulsa, OK, USAChristopher WilsonDepartment of Nerve Surgical Treatment, Keck Institution of Medicine of the College of Southern California, Los Angeles, CA, USAAaron Cohen-GadolDepartment of Neurological Surgical Operation, Indiana University College of Medicine, Indianapolis, IN, USAMohamed A. ZaazoueDepartment of Orthopedic Surgical Treatment, Washington College Institution of Medication in St. Louis, St. Louis, MONTH, USAMohamed A. ZaazoueGerman Cancer Range (DKTK), DKFZ Partner Internet Site Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiCluster of Superiority (EXC 2180) u00e2 $ Photo Led and also Functionally Instructed Tumor Therapiesu00e2 $, Eberhard Karls Educational Institution Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh TabatabaiDepartment of Neurology and Interdisciplinary Neuro-Oncology, Center for Neuro-Oncology, Comprehensive Cancer Cells Center, Hertie Institute for Clinical Mind Investigation, Eberhard Karls University Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyGhazaleh Tabatabai, u00c2 Sylvia C. Kurzu00c2 &amp u00c2 Paul PasslackDepartment of Neurosurgery, Facility for Neuro-Oncology, Comprehensive Cancer Cells Facility, Eberhard Karls University Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyMarcos Tatagiba, u00c2 Felix Behling, u00c2 Mirjam Renovanz, u00c2 Jens Schittenhelmu00c2 &amp u00c2 Paul PasslackDepartment of Pathology, Educational Institution of San Francisco, San Francisco, CA, USADamian A. Almiron BonninHuman The Field Of Biology Division, Fred Hutchinson Cancer Cells Facility, Seat, WA, USAEric C. HollandDepartment of Person Oncology, College of Wisconsin Hospitals and Clinics, Madison, WI, USATim J. KruserCentral Mind Growth Windows Registry of the USA, Hinsdale, IL, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanTrans Divisional Analysis Plan (TDRP), Division of Cancer Epidemiology and Genetic Makeup (DCEG), National Cancer Principle, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanCenter for Biomedical Informatics &amp Information Technology (CBIIT), National Cancer Institute, Bethesda, MD, USAJill S. Barnholtz-Sloanu00c2 &amp u00c2 Jill Barnholtz-SloanPiedmont Human Brain Tumor Facility, Piedmonth Healthcare System, Atlanta Ga, GA, USAAndrew E. Sloanu00c2 &amp u00c2 Andrew E. SloanDepartment of Pathology, Northwestern University, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiLou &amp Jean Malnati Human Brain Cyst Institute at the Lurie Comprehensive Cancer Cells Center, Northwestern College, Evanston, IL, USACraig Horbinskiu00c2 &amp u00c2 Craig M. HorbinskiDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USASilky Chotaiu00c2 &amp u00c2 Lola B. ChamblessDepartment of Lab Medication and also Pathobiology, College of Toronto, Toronto, Ontario, CanadaAndrew GaoDivision of Neurosurgery, University of British Columbia, Vancouver, British Columbia, CanadaAlexander D. Rebchuku00c2 &amp u00c2 Serge MakarenkoDepartment of Pathology &amp Laboratory Medicine, Faculty of Medicine, College of British Columbia, Vancouver, British Columbia, CanadaStephen YipDepartment of Neuropathology, Institute of Pathology, Ruprecht-Karls-University Heidelberg, Heidelberg, GermanyFelix Sahm, u00c2 Felix Sahmu00c2 &amp u00c2 Andreas von DeimlingClinical Cooperation Unit Neuropathology, German Cancer Cells Proving Ground (DKFZ), Heidelberg, GermanyFelix SahmDepartment of Pathology, Leiden Educational Institution Medical Center, Leiden, The NetherlandsSybren L. N. MaasDepartment of Pathology, Erasmus MC Cancer Cells Principle, College Medical Center Rotterdam, Rotterdam, The NetherlandsSybren L. N. MaasRadiation Medication Program, Little Princess Margaret Cancer Cells Facility, Toronto, Ontario, CanadaDerek S. TsangRadiation Oncology, Utah Cancer Cells Specialists, Sodium Pond City, UT, USAC. Leland RogersCenter for Cancer Cells Analysis, National Cancer Cells Institute, Bethesda, MD, USAKenneth AldapeMiami Neuroscience Institute, Baptist Health, Miami, FL, USAMichael W. McDermottDepartment of Neurosurgery, Addenbrookeu00e2 $ s Healthcare facility, Cambridge, UKThomas Santariusu00c2 &amp u00c2 Daniel M. FountainDepartment of Neurosurgery, University Hospitals Cleveland and also Instance Western Book Educational Institution, Cleveland, OH, USAWarren SelmanDepartment of Pathology, Educational Institution Hospitals Case Medical Center, Cleveland, OH, USAMarta CouceDepartment of Neurosurgery, Centro Hospitalar Universitu00c3 u00a1 rio S. Jou00c3 u20a4 o, Porto, PortugalBruno CarvalhoCenter for Neuro-Oncology, Dana-Farber/Brigham as well as Womenu00e2 $ s Cancer cells Facility, Boston, MA, USAPatrick Y. WenDepartment of Neurosurgery, Duke Educational Institution, Durham, NC, USAKyle M. WalshDepartment of Neurosurgery, Erasmus MC Cancer Principle, Erasmus College Medical Facility, Rotterdam, The NetherlandsEelke M. BosDepartment of Neurosurgery, Brigham as well as Womenu00e2 $ s Healthcare facility, Harvard Medical University, Boston Ma, MA, USAWenya Linda BiDepartment of Radiology, Brigham and also Womenu00e2 $ s Medical facility, Dana-Farber Cancer Principle, Harvard Medical University, Boston Ma, MA, USARaymond Y. HuangDepartment of Neurology, Department of Neuro-Oncology, Massachusetts General Medical Center, Harvard Medical College, Boston, MA, USAPriscilla K. BrastianosDepartment of Radiation Oncology, Massachusetts General Medical Center, Boston, MA, USAHelen A. ShihDepartment of Neurology, Hermelin Human Brain Lump Facility, Holly Ford Health, Detroit, MI, USATobias WalbertDepartment of Neurosurger, Hermelin Mind Lump Facility, Holly Ford Wellness, Detroit, MI, USAIan Lee, u00c2 Ana Valeria Castro, u00c2 Houtan Noushmehru00c2 &amp u00c2 James M. SnyderDepartment of Pathology, College of Texas Medical Division, Galveston, TX, USAMichelle M. FelicellaDepartment of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyFrancesco Dimecou00c2 &amp u00c2 Andrea SaladinoNeuropathology System, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, ItalyBianca PolloDepartment of Neurosurgery, LMU Teaching Hospital, LMU Munich, Munich, GermanyChristian Schichoru00c2 &amp u00c2 Ju00c3 u00b6 rg-Christian TonnDepartment of Radiation Oncology, Charitu00c3 u00a9 u00e2 $ "Universitu00c3 $ tsmedizin Berlin, Corporate Participant of Freie Universitu00c3 $ t Berlin and also Humboldt-Universitu00c3 $ t zu Berlin, Berlin, GermanyFelix EhretDepartment of Radiology, Mayo Center, Rochester, MN, USATimothy J. KaufmannDepartment of Lab Medicine and Pathology, Mayo Facility, Rochester, MN, USADaniel H. Lachance, u00c2 Caterina Gianniniu00c2 &amp u00c2 Aditya RaghunathanDepartment of Oncology, Branch of Medical Oncology, Mayonnaise Facility, Rochester, MN, USAEvanthia GalanisDepartments of Neuro-Oncology as well as Neurosurgery, Moffitt Cancer Facility, Tampa, FL, USAMichael A. VogelbaumNeuropathology Device, Surgical Neurology Division, National Institute of Nerve Ailments as well as Movement, National Institutes of Health And Wellness, Bethesda, MD, USAPatrick J. CiminoDepartment of Neurological Surgical Operation, Northwestern College, Northwestern Medication, Chicago, IL, USAMark YoungbloodDepartment of Pathology, NYU Langone Medical Facility, Nyc, NY, USAMatija SnuderlDepartment of Radiation Oncology, NYU Langone Health And Wellness, New York University, The Big Apple, NY, USAErik P. SulmanDepartment of Neurosurgery, College of Oklahoma Health And Wellness Sciences Center, Oklahoma Metropolitan Area, OK, USAIan F. DunnPeninsula Schools of Medicine as well as Dentistry, Plymouth University, Plymouth, UKC. Oliver HanemannDepartment of Neurosurgery, Royal University of Surgeons in Ireland, Dublin, IrelandMohsen JavadpourDepartment of Anatomical as well as Mobile Pathology, Chinese College of Hong Kong, Shatin, Hong KongHo-Keung NgDepartment of Individual Genes, University of The Golden State, Los Angeles, Los Angeles, CA, USAPaul C. BoutrosDepartment of Neurosurgery, Educational Institution of The Golden State, Los Angeles, Los Angeles, USARichard G. EversonDepartment of Neurosurgery, Teaching Hospital of Larissa, School of Medication, University of Thessaly, Larissa, GreeceAlkiviadis Tzannisu00c2 &amp u00c2 Konstantinos N. FountasDepartment of Neurosurgery, Educational Institution Medical Center Regensburg, Regensburg, GermanyNils Ole SchmidtDepartment of Surgical Operation, Department of Neurosurgery, College of Alberta, Edmonton, Alberta, CanadaKarolyn AuCenter of Neurosurgery, Division of General Neurosurgery, College of Perfume, Cologne, GermanyRoland GoldbrunnerDepartment of Neurology, Professors of Medicine, Teaching Hospital Cologne, Educational Institution of Perfume, Fragrance, GermanyNorbert GalldiksLaboratory for Neurooncology and also Experimental Neurosurgery, Department of General Neurosurgery, Center for Neurosurgery, Perfume, GermanyMarco TimmerDepartment of Neurosurgery, Teaching Hospital of Copenhagen-Rigshospitalet, Copenhagen, DenmarkTiit Illimar MathiesenDepartment of Neurosurgery, College Medical Facility Hamburg-Eppendorf, Hamburg, GermanyManfred Westphal, u00c2 Katrin Lamszusu00c2 &amp u00c2 Franz L. RicklefsDepartment of Neurosurgery, Teaching Hospital Heidelberg, Heidelberg, GermanyChristel Herold-Mende, u00c2 Christine Jungku00c2 &amp u00c2 Gerhard JungwirthDepartment of Radiation Oncology, Heidelberg Teaching Hospital, Heidelberg, GermanyMaximilian DengLeeds Institute of Medical Investigation at St. Jamesu00e2 $ s, Educational institution of Leeds, Leeds, UKSusan C. ShortDepartment of Neurosurgery, The Walton Facility NHS Structure Rely On, Liverpool, UKMichael D. JenkinsonInstitute of Neuropathology, Otto-Von-Guericke-University, Magdeburg, GermanyChristian MawrinDepartment of Neurosurgery, Manchester Facility for Clinical Neurosciences, Salford Royal Healthcare Facility NHS Groundwork Leave, Salford, UKAbdurrahman I. Islimu00c2 &amp u00c2 Omar N. PathmanabanDepartment of Neurosurgery, Royal Melbourne Health Center, Melbourne, VIC, AustraliaKatharine J. Drummondu00c2 &amp u00c2 Andrew MorokoffDepartment of Radiation Oncology, Educational Institution of The Golden State, San Francisco, San Francisco, CA, USADavid R. RaleighDepartment of Neurosurgery, College of The Golden State, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Nicholas A. ButowskiDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USADavid R. Raleighu00c2 &amp u00c2 Arie PerrySchool of Pharmaceutical Sciences of Ribeiru00c3 u20a4 o, Preto Educational institution of Su00c3 u20a4 o Paulo, Su00c3 u20a4 o Paulo, BrazilTathiane M. MaltaDepartment of Pathology and Laboratory Medication, Educational Institution of Saskatchewan College of Medication, Saskatoon, Saskatchewan, CanadaViktor ZherebitskiyDivision of Neurosurgery, Royal Teaching Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaLuke HnennyUSC Pituitary Center, USC Radiosurgery Facility, Keck College of Medication of USC, Los Angeles, CA, USAGabriel ZadaDepartment of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, Hamm, GermanyAntonio SantacroceNuclear Medicine and Professional Molecular Imaging, Team of Radiology, Eberhard Karls University of Tu00c3 1/4 bingen, Tu00c3 1/4 bingen, GermanyChristian Los Angeles Fougu00c3 u00a8 reDepartment of Neurosurgery, Yale School of Medication, New Place, CT, USAJennifer MoliternoDepartment of Neurosurgery, Tufts Medical Center, Boston, MA, USAAlper DincerArthur as well as Sonia Labatt Brain Tumour Research Center, The Healthcare Facility for Sick Children, Toronto, Ontario, CanadaGelareh ZadehManuscript writing, figure planning, standard analytical review and also general bioinformatics were executed by J.Z.W. Molecular category, design building and also bioinformatics support was delivered by V.P., A.P.L. and also J.L. TERT promoter sequencing was executed through C.G. Copy amount variant study and referring to as were done through A.P.L. Molecular analyte removal, metrology and sequencing were carried out through J.Z.W., A.P.L., C.G., A.A. and Z.P. DKFZ methylation training class and also subclass determination was actually conducted by R.Y. and also R.K. making use of the openly on call online resource generated through F.S. RNA sequencing study was carried out through V.P. and J.L. Biostatistical customer review was done through O.S. Medical records coming from the NRG Oncology RTOG-0539 meningioma instances were actually delivered by S.L.P. and also M.W. Scientific meningioma examples as well as matching scientific data were offered through C.W., A.C.G., M.A.Z., G.T., M.T., F.B., D.A.A.B., E.C.H., J.B.S., A.E.S., C.H., S.C., L.B.C., A.R., S.M. and also S.Y. Pathologic review was conducted by A.G. and K.A. Radiotherapy data of institutional retrospective meningioma cases were actually supplied through D.S.T. Research concept and also perception were actually carried out through J.Z.W, F.N. and also G.Z. All of authors joined document customer review and alterations in some ability.

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